CALCITONIN CENE-RELATED PEPTIDE IN SMALL INTESTINE OF RATS——A Study On the Distribution, Origins and Properties
- VernacularTitle:大鼠小肠降钙素基因相关肽分布来源及性质的研究
- Author:
Kang WU
;
Wenqin CAI
- Publication Type:Journal Article
- Keywords:
Rat;
Small intestine;
Calcitonin gene-related peptide;
Immunocytochemistry;
Radioimmunoassay
- From:
Acta Anatomica Sinica
1989;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
By using immunocytochemistry (the whole mount stretch preparations and cryostat sections) and radioimmunoassay, the characteristics of distribution, origins and properties of calcitonin gene-related peptide (CGRP) were studied. The results show that all layers of small intestine were rich in CGRP-immu-noreactive(CGRP-I)nerves with a high density in myenteric, submucosal and mucosal plexuses. Also it had a rather high density around the small blood vessels of the small intestine and intestinal crypts. Some CGRP-I neurons were seen in the myenteric and submucosal plexuses which were the intrinsic origin of CGRP-I nerves of small intestine. And the denervation and injection of capsaicin demonstrated that the extrinsic CGRP-I nerves of small intestine with mainly sensory origin also existed. The characteristics of distribution of CGRP-I nerves in small intestine indicated that the CGRP-I nerves might be related with the regulation of motion, secretion, absorption, sensation and regional blood flow of the gastrointestinal tract.
