DISTRIBUTION OF FIBRONECTIN ON VESSEL WALL AND PLATELET SURFACE
- VernacularTitle:纤维连接素在血管壁和血小板表面的分布
- Author:
Hexin GUO
;
Jin LI
- Publication Type:Journal Article
- Keywords:
Fibronectin;
Vessel;
Platelet
- From:
Acta Anatomica Sinica
1989;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
The distribution and types of fibronectin (Fn) on vessel wall and platelt surface in human being and rat were studied with rabbit anti-human and rabbit anti-rat Fn antisera and monoclonal antibody against human Fn. It was found that the Fn of mainly cellulartype is chiefly distributed within the layer of subendothelium and near the luminal surface of aorta. In connective tissue of the adventitia there was a large amount of Fn of the plasma and cellular types. The distribution of Fn in the wall of the middle-sized arteries was similar to that in the aortic wall. The Fn of the cellular type in the human aortic subendothelium was more abundant than that in the rat. There were only little amount of Fn on the surface of resting platelet. Nevertheless, when they were activated by thrombin, the amount of Fn on their surface increased, chiefly of the plasma type. The r sult of this work seems to have practical significance in the investigation of the mechanism of platelet adhesion on vessel subendothelium matrix.
