ONTOGENETIC STUDIES OF GASTRIN CELLS AND SOMATOSTATIN CELLS IN THE HUMAN FETAL GASTROINTESTINAL TRACT
- VernacularTitle:胎儿胃肠道胃泌素细胞与生长抑素细胞的免疫组织化学研究
- Author:
Fusheng WANG
;
Yumin LI
- Publication Type:Journal Article
- Keywords:
Ontogeny;
Gastrin cell;
Somatostatin cell;
Gut;
Immunohistochemistry;
Human fetus
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Ontogenesis of gastrin cells (G cells) and somatostatin cells (D cells) in the gastrointestinal tract was studied by PAP and indirect immunofluorescence method in sixty human fetuses aged 8-38 weeks of gestation. The appearance of D cells and G cells was observed as early as 8-9 weeks of gestation. These cells were not seen in the submucosa and the tunica muscularis except the epithelium of gut. After 12 weeks of gestation, D cells can be found in the mucosa of the whole gut, whereas G cells only in the mucosa of the antrum and small intestine. The distribution, number and the ratio of G cells to D cells were also examined. In addition, we have observed that G cells in the antral mucosa often possessed processes which were considered to have paracrine function. The G cells and D cells were open-type endocrine cells in the human fetal gut except the D cells in the fundic mucosa. The possible function of G cells and D cells in the development of gut was discussed. The ratio of the two cell types in adult human antrum and upper duodenum has also been compared with that of fetus.
