HISTOLOGICAL STUDY ON THE EFFECT OF A HIGH DOSAGE OF LH-RH-A IN ENDOME-TRIUM ON PSEUDOPREGNANT RATS
- VernacularTitle:大剂量促黄体生成素释放激素类似物对假孕大鼠子宫内膜影响的组织学研究
- Author:
Jing HE
;
Maowei WANG
- Publication Type:Journal Article
- Keywords:
Luteinizing hormone releasing hormone analogue (LH-RH-A);
Pseudopregnancy;
Decidua;
Stromal cells;
Endometrial granulated cells;
Rats
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The decidua of pseudopregnant rats and of those effected by high dosage of luteinizing hormone-releasing hormone analogue (LH-RH-A) were studied histologically.After inducement of pseudopregnancy, 29 Wistar virgin rats were divided into experimental and control groups. The experimental group was injected with 200?g. of LH-RH-A subcutaneously daily for four days, while to the control group, physiological saline was injected instead. Both experimental and control animals were killed on the 9th, 11th and 13th day of pseudopregnancy.The uteri were fixed with appropriate fixatives and paraffin sections were processed with HE, phloxine-tartrazine, Foots and aldehyde fuchsin staihing methods.On the 9th day decidua of the control rats are well developed with many endometrial granulated cells, while in the decidua of the experimental group, the decidual cells become pyknotic, and the granulated cells are barely seen. The results suggest that a high dosage of LH-RH-A advances the necrosis of decidua of the pseudopregnant rats.
