THE PEPTIDERGIC INNERVATION OF CEREBRAL VESSELS——LIGHT MICROSCOPIC AND IMMUNOELECTRON MICROSCOPIC STUDY
- VernacularTitle:大鼠脑血管的肽能神经支配——光镜与免疫电镜研究
- Author:
Jinhuo LU
;
Changgeng ZHU
;
Qingying LIU
;
Jiaxiang ZHU
;
Hantao LIU
;
Aqing CHEN
- Publication Type:Journal Article
- Keywords:
Vasoactive intestinal polypeptide;
Substance P;
Immunohistochemistry;
Immunoelectron microscopy;
Cerebral vessel
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Using the immunohistochemical and immunoelectron microscopic methods, the localization and pattern of vasoactive intestinal polypeptidergic nerves in the wall of cerebral vessels were investigated. The results revealed that the VIP-like immunoreactive (VIPLI) fibres were located in the adventitia or at the adventitia-media border. No synaptic contacts were identified among the nerve terminals or between nerve terminal and smooth muscle cell. VIPLI terminals directly apposed to the smooth muscle cells with a distance of 100 nm.The observations mentioned above indicate that there is peptidergic innervation in the wall of the cerebral vessels besides traditional adrenergic and cholinergic innervations. The regulatory function of VIP-containing nerves to the cerebral vessels may be performed by affecting the smooth muscle directly through the nonsynaptic release. In addition, present study identified and discussed the distribution and function of substance P(SP) in the cerebral vessels.
