TRAUMATIC CEREBRAL CORTEX OF ADULT RATS LABELED WITH H~3-THYMIDINE FOR TRACING THE ORIGIN OF THE MITOTIC NEURONS
- VernacularTitle:成年大鼠大脑皮质创伤后其分裂神经元的来源——~3H-胸腺嘧啶核苷示踪研究
- Author:
Lianbi HUANG
;
Jing XU
- Publication Type:Journal Article
- Keywords:
Cerebral Cortex;
Neurons;
Mitosis
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
H~3-thymidine was used in determining the neuronal mitosis of the traumati cerebral cortex in rats. Intraperitoneal injection of H~3-thymidine was given to the rats immediately after corticectomy of the parietal lobes. On the 4th day after operation, the cerebral tissue was removed, fixed in Carnoy, serial sectioned, and stained with cresyl violet.The results showed that in the surrounding area 100—200?m from the traumatic site, 2-5％ of the various types of cells in the cerebral tissue were labeled, i. e. silver granules were distributed within the nuclei. Macrophages, endothelial cells and pericytes of vessels make up most of the 2—5％, whereas neuroglia and neuron rank next. The nuclei of the majority of the labeled cells were in the interphase state and a few of them were in the mitotic state. The more the labeled cells are in the interphase state,, the more the mitosis occur. On the contrary, it is less. They are always in direct proportion. In the case of neurons the same situation occurs.By inference, the mitotic division of the neurons in the cerebral cortex may occur in situ. Possibly some kind of substance is produced after the trauma leads to the division of the mature neurons. The basis for this inference is that a certain number of the neurons in division have typical features of the pyramidal neurons.
