ULTRASTRUCTURAL STUDIES OF THE INJURIOUS ACTION OF CADMIUM AND PROTECTIVE ACTION OF ZINC ON RAT TESTIS
- VernacularTitle:镉对大鼠睾丸的损伤及锌保护作用的超微结构研究
- Author:
Weixin LI
;
Xiaogang LIAO
;
Yi TANG
;
Daqian BAO
- Publication Type:Journal Article
- Keywords:
Cadimum;
Zinc;
Testis;
Ultrastructural changes;
Rat
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper presents the ultrastructural studies of the immediate and delayed effects of Cadmium (Cd) on rat testes and the protective effects of Zinc (Zn) on Cd induced injury. Forty-two rats were divided into three groups: 1) treatment with Cd (2mg/kg body weight); 2) treatment with Cd combined with Zn (80mg/kg body weight); and 3) the controls.The ultrastructural changes of some spermatids, spermatogonia primary spermatocytes and peritubular tissue were detected within 10—30 minutes after Cd treatment. The morphlogical alterations of spermatids and primary spermatocytes appeared first. However, after 1 hour, the changes of testicular capillaries were observed, and those of the Leydig cells were found within 2—4 hours. After 3—7 days, the seminiferous epitheium, peritubular tissue and interstitial tissue were totally necrosed. These results suggest that both seminiferous tubules and testicular capillaries are damaged directly by Cd treatment, but the ultrastructural alterations of the capillaries appear later than those of the seminiferous tubules. The protective effect of Zn on the testicular injury induced by Cd is prominent. However, this effect on the early spermatids is weaker than that on the other germ cells.
