HISTOLOGICAL AND HISTOCHEMICAL STUDIES OF EFFECTS OF THE HIGH DOSE OF LRH-A ON THE CORPUS LUTEUM OF PREGNANT RATS
- VernacularTitle:大剂量促黄体素释放激素九肽类似物对受孕大鼠黄体影响的组织学和组织化学观察
- Author:
Rongxin YAN
;
Minzhi SUN
;
Aihua FU
- Publication Type:Journal Article
- Keywords:
LRH-A;
Corpus luteum;
Histochemistry;
Rat
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present experiment the high dose of LRH-A was injected into pregnant rats on Day 9 of pregnancy. Morphology and histochemistry of corpus luteum were studied. It was found that 24 hours after injection LRH-A could effectively cause the corpus luteum to degenarate. A great many large lipid droplets occured in the luteal cells, and the activity of 3?-HSD and of SDH of these cells decreased. At the same time the activity of AcP increased in a few of luteal cells. 48 hours after injection the effects outlined above became more distinct, and the activity of G-6-PD also began to decrease. The activity of 20 ?-HSD in both control and experimental groups was negative 24 hours after injection, while the activity of the AIP increased distinctly in endothelium of the capillary network of corpus luteum. These changes indicated that the high dose of LRH-A had damaged corpus luteum and reduced its synthetic and secretory function of progesterone which, we believe, plays a main role in terminating pregnancy.
