ULTRASTRUCTURAL OBSERVATIONS OF THE GOSSYPOL EFFECT ON THE RAT HYPOTHALAMUS
- VernacularTitle:棉酚对大鼠下丘脑超微结构影响的观察
- Author:
Tianbao SONG
;
Qianwu LI
- Publication Type:Journal Article
- Keywords:
Gossypol;
Hypothalamus;
Arcuate nucleus;
Supraoptie nucleus;
Paraventricular nucleus;
Ultrastructure
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Observations of the ultrastructural changes in neurons of hypothalamie arcuate, supraoptic and paraventricular nuclei were carried out in the rats following gossypol treatment at a dosage of 30mg/kg/day for 5 weeks. The results showed that after gossypol treatment no marked changes in supraoptic and paraventricular cells could be seen at electron microscopic level, and that there appeared a series of ultrastrucrural changes reflecting increased neurosecretory activity in some of arcuate neurons.They were as follows: Golgi complex and rough endoplasmic reticulum were slightlydilated and filled with homogeneous, low electron density materials in their cisternae; the amounts of neurosecretory granules, lysosomes, nucleolus-like bodies, and microtubules were increased. The nature, significance and cause of these changes are discussed.
