ULTRASTRUCTURAL OBSERVATIONS ON THE GONADOTROPHIC CELLS OF ADENOHYPOPHYSIS AND THE INTERSTITIAL CELLS OF TESTIS IN RATS FOLLOWING GOSSYPOL TREATMENT
- VernacularTitle:醋酸棉酚对大鼠垂体促性腺细胞及睾丸间质细胞超微结构影响的观察
- Author:
Shijun YE
;
Meimei YOU
;
Sherpu SHIEH
- Publication Type:Journal Article
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Observations of the ultrastructural changes on the gonadotrophic cells of adenohypophysis and the interstitial cells of testis were carried out in rats following gossypol treatment.It was found that four types of gonadotrophs in the rat adenohypophysis could be classified under the electron microscopic observation. The contral groups mainly consisted of the types Ⅰ and Ⅱ gonadotrophic cells and the latter appear to be the most numerous cell type, which constitute about 65% of the total gonadotrophs. Following gossypal administration, the number of type Ⅱ cells decreased obviously while that of the type Ⅲ cells increased steady and became the principal type of gonadotrophic cells in gossypol-treated animals. The proportion of the type Ⅲ cells were calculated as 56%, 44% and 58% of the total gonadotrophs after Ⅰ, 2 and 12 months of gossypol treatment, respectively. The type Ⅳ cells were characterized by the appearance of dilated vesicles derived from rough endoplasmic reticulum which occupied almost the entire cytoplasm. Morphologically, these cells were similar to "castration cells" which appeared in the rat adenohypophysis after gonadectomy. They were observed in the experimental animal groups following two months of gossypol treatment, and their proportion was about 13% of the gonadotrophs.No significant ultrastructural changes in the interstitial cells of the treated rat testis could be observed.The significance of the above mentioned changes and the possible mechanism of gossypol effect on the gonadotrophs were discussed.
