THE DESTINY OF CANCER CELLS AND CHANGES OF LYMPH NODES IN THE PROCESS OF LYMPHATIC METASTASIS
- VernacularTitle:在淋巴道转移过程中癌细胞在淋巴结内的命运及淋巴结的改变
- Author:
Yilin SUN
- Publication Type:Journal Article
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
The purpose of this experiment is to study the destiny of cancer cells and changes of lymph node after lymphatic metastasis.Ehrlich ascitic carcinoma cells were injected intradermally into the right footpad of mice. We try to estabilish a model about lymphatic metastasis in the popliteal lymph node.The lymph nodes of the drainage area were taken out at different time intervals and examined by light microscopy, transmission electron microscopy as well as scanning electron microscopy. Onehour after the injection cancer cells were found in the popliteal lymph node. Mitotic figures of cancer cells were discovered in fifth hours and the tumor cells had reached to second lymph node——lumber lymph node or parailiac lymph node. The metastasis were formed in 24 hours after injection. The tumor cells first migrated in the subcapsular sinus of lymph node, then they entered the intermediate and medullary sinuses. Besides, the lymph nodes showed active reactionary proliferation, hyperplasia of histocytes and enlargement of germinal centers after three days. There were many small lymphocytes assuming the form of active amebae, surrounding the postcapillary venules. Degeneration and necrosis of cancer cells was observed at same time.Under the electron microscope many lymphocytes were observed to adhere closely to the cancer cell and their Golgi apparatus and mitochondria were accumulated towards the cell memberane opposing the cancer cell, as if some substance were released to it.This experimental result showed that lymph node probably prosess ability to defend metastasis of cancer cells.
