COMPARATIVE HISTOCHEMICAL OBSERVATIONS ON THE CHANGES OF MUCOSUBSTANCES IN FETAL GASTRIC MUCOSA AND GASTRIC ADENOCARCINOMA
- VernacularTitle:胃组织发生中的粘液变化及其与胃癌组织中的粘液物质的比较
- Author:
Jiaji HOU
- Publication Type:Journal Article
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Specimens of gastric mucosa were obtained from 16 cases of fetal stomach, aging from 11 weeks to full term, 5 cases from gastric adenocarcinoma, one case from gastritis and one case from normal adult. The contents of their mucosubstances were compared histochemically with Mowry's alcian blue and PAS techniques. The results are as follows:The mucosubstances of gastric mucosa undergo a conspicions change during the fetal life. In general, acid mucopolysaccharide appear at first in the epithelium and rudimentary gastric pits and it is replaced subsequently by neutral mucin. This mucosaccharide replacement varies within different areas and stages. The neutral mucin always takes its appearance about the 11th week at the cardiac and pyloric regions where the mucosubstance have begun to reveal pruple colour in AB-PAS reaction. After the 4th month, the neutral mucosacchaide has completed its replacement in both areas except the lower parts of pyloric glands which still show some mixed mucins. In the corpus tomach, acid mucin is present almost during the whole fetal life but converts into mixed type only at birth. The parietal cell do not contain any mucous material during its histogenesis, but the chief cell may contain some alcianophilic granules which will change into faintly PAS-positive at birth. With alcian blue at low pH, it proves that most of the acid mucosaccarides are sulfated mucosubstance.Adjacent to the bottoms of gastric pits and the necks of gastric glands, some acid mucin often remains in 1he epithelial and neck mucous cells of normal adult just as those of newborn. The acid mucosubstance occurs in various degree within the spaces or lumen of adenocarcinoma tissue. It could be considered that the bottoms of pits and necks of glands would be a cellular bases for further development of gastric carcinnoma under certain conditions.
