THE HISTOCHEMICAL STUDY OF ?-GLUCURONIDASE IN THE TISSUE OF GASTRIC CARCINOMA
- VernacularTitle:胃癌组织内?-葡萄糖苷酸酶的组织化学研究
- Author:
Yiquan CHEN
- Publication Type:Journal Article
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Twenty-two samples from tissues of carcinoma of the stomach and twenty samples from tissues of the stomach of the patients of duodenal ulcer were utilized for this study. In the later, specimens were taken from the large curvature and pylorus. The tissue of carcinoma of the stomach were obtained from the cancer focus, the cancer margins, the mucosa that was far from carcinoma focus and pylorus sinus. Frozen sections were cut. The ?-glucuronidase was demonstrated with Fischman's histochemical method with modifications.In carcinoma tissue of stomach, there are sufficient ?-gluearonidase (?-GU). ?-GU are mainly distributed in cancer cells. Some of ?-GU are distributed in the interstitial tissue of cancer. In every cancer cell, their activity of ?-GU have an obvious differentiation. Liberation procedure of ?-GU in the well-developed cancer cells have a constant direction, that is same as the pylorus glands, but it is not so in the lower developed cancer cells. Overlapping on the mucosa of carcinoma of the stomach there is a layer of membrane-like substance that shows a stronger activity of ?-GU. The activity of ?-GU in the mucosa of center of cancer focus is the lowest, whereas there is an obvious increase in the mucosa of cancer margin as well as tissue far away from the cancer focus.In the stomach of patients of the duodenal ulcer, the pylorus rnucosa contains a sufficient amount of ?-GU, which is mainly distributed in pylorus glands and cellular elements of lamina propria, so that the enzyme activity appears lower in the mucosa of stomach and shows a zonal distribution.In this paper the pathological and physiological signification of ?-GU in th tissue of stomach carcinoma has been discussed.
