Increased Prevalence of Colorectal Neoplasia in Korean Patients with Sporadic Duodenal Adenomas: A Case-Control Study.
- Author:
Woo Chul CHUNG
1
;
Bo In LEE
;
Sang Young ROH
;
Jae Wuk KWAK
;
Sun Mee HWANG
;
Yoon Ho KO
;
Jung Hwan OH
;
Hyunjung CHO
;
Hiun Suk CHAE
;
Young Seok CHO
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. yscho@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Duodenal neoplasms;
Colorectal neoplasms;
Colonoscopy;
Endoscopy
- MeSH:
Adenoma;
Case-Control Studies;
Colonoscopy;
Colorectal Neoplasms;
Duodenal Neoplasms;
Endoscopy;
Hospitals, Teaching;
Humans;
Mass Screening;
Odds Ratio;
Prevalence;
Republic of Korea;
Retrospective Studies
- From:Gut and Liver
2011;5(4):432-436
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Recent data from Western populations have suggested that patients with sporadic duodenal adenomas are at a higher risk for the development of colorectal neoplasia. In this study, we compared the frequency of colorectal neoplasia in patients with sporadic duodenal adenomas to healthy control subjects. METHODS: This retrospective case-control study used the databases of 3 teaching hospitals in Gyeonggi-do Province, South Korea. The colonoscopy findings of patients with sporadic duodenal adenomas were compared with those of age- and gender-matched healthy individuals who had undergone gastroduodenoscopies and colonoscopies during general screening examinations. RESULTS: Between 2001 and 2008, 45 patients were diagnosed endoscopically with sporadic duodenal adenomas; 26 (58%) of these patients received colonoscopies. Colorectal neoplasia (42% vs 21%; odds ratio [OR], 2.8; 95% confidence interval [CI], 1.1 to 7.4) and advanced colorectal adenoma (19% vs 3%; OR, 9.0; 95% CI, 1.6 to 50.0) were significantly more common in patients with sporadic duodenal adenomas than in healthy control subjects. CONCLUSIONS: Compared with healthy individuals, patients with sporadic duodenal adenomas were at a significantly higher risk for developing colorectal neoplasia. Such at-risk patients should undergo routine screening colonoscopies.
