Meta analysis of the efficacy of sequential therapy for eradication of Helicobacter pylori
- VernacularTitle:序贯治疗根除幽门螺杆菌感染的Meta分析
- Author:
Liping WU
;
Rui ZHAO
;
Yiping WANG
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
meta-analysis;
sequential therapy
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the curative effect of sequential treatment and standard triple therapy in eradicating Helicobacter pylori and the risk of adverse events between the two therapies.Methods The related studies were searched with electronic databases to evaluate the efficacy of sequential therapy and standard triple therapy in eradicating H.pylori.Information was retrieved including the clinical features of patients,quality of research,eradication rate of H.pylori and incidence of adverse events and so on.The pooled relative risk(RR)and 95%confidence intervals(95%CI)were calculated,and the publication bias was assessed with funnel plot. Results Twelve randomized trials were performed,and 3183patients met the internalization criterion.Meta analysis demonstrated a clear superiority of the sequential therapy over 7-day triple therapy with an RRof 1.23(95%CI:1.19-1.27),over 10-day triple therapy with aRRof 1.17(95%CI:1.10-1.24),and over 14-day triple therapy with a RRof 1.25(95%CI:1.06-1.48).The incidence of adverse event was similar with sequential therapy versus that of triple therapy(RR=0.96,95% CI:0.75-1.23).Conclusions Sequential therapy is associated with a higher eradication rate of H.pylori compared with 7-day,10-day and 14-day triple therapy.The adverse event doesn't increase significantly.
