Effects of Shenqi Compound Recipe on expression of COX-2 mRNA in aorta in GK rats
- VernacularTitle:参芪复方对GK大鼠主动脉COX-2 mRNA表达的影响
- Author:
Min CHEN
;
Hong GAO
;
Chunguang XIE
;
Ya LIU
;
Can ZHUANG
- Publication Type:Journal Article
- Keywords:
Shenqi Compound Recipe;
Diabetes macroangiopathy;
C reactive protein;
Cycloxygenase-2
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of Shenqi Compound Recipe on the expression of Cycloxygenase-2 (COX-2)mRNA in aorta in GK rats.There were five groups:GK group,model group,atorvastatin group,Shenqi Compound Recipe group and normal control group.During the experiment periods,each group was administrated correspondent substance respectively for 35 days.Serum concentrations of C reactive protein(CRP)were determined by ELISA.The mRNA expressions of COX-2 in aorta were detemined by reverse transcriptase PCR(RT-PCR).Results:Compared with model group,concentrations of CRP in serum and the mRNA expression of COX-2 all decreased in atorvastatin group and Shenqi Compound Recipe group(P
