Effects of Buguozhi Decoction on gene expression of ER-?,NR2B in hippocampus of vascular dementia model rats
- VernacularTitle:补骨脂汤对血管性痴呆大鼠海马内雌激素受体-?、NMDAR2B基因表达的影响
- Author:
Lixiang ZHENG
;
Kesui DENG
;
Yudan QIAO
;
Min SHI
;
Zhiyuan CUI
- Publication Type:Journal Article
- Keywords:
Buguozhi Decoction;
Vascular dementia;
Expression of ER-?,NR2B gene
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mechanism of Buguozhi Decoction in improving learning-memory of vascular dementia model rats.Methods:The rat models with VaD were established by bilateral occlusion of both common carotid arteries(2 一V0).The gene expressions of ER-?,NR2B were evaluated by RT-PCR and immunohistochemistry.Results:Buguozhi Decoction can significantly improve mRNA and protien pruducts of ER-?,NR2B gene in hippocampus of the vascular dementia model rats,compared with the model group(P
