The effect of oxysophoridine on electric activities and its power spectrums of cerebral frontal cortex in rats
- VernacularTitle:氧化槐定碱对大鼠额叶皮层脑电活动及功率谱的影响
- Author:
Jianqiang YU
;
Yuxiang LI
;
Wanping ZHU
;
Ling HUANG
;
Feng WANG
;
Yuanxu JIANG
- Publication Type:Journal Article
- Keywords:
oxysophoridine;
frontal lobe of cerebral cortex;
electroencephalogram( EEG);
power spectrum;
frequency distributions;
rats
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effect of oxysophori-dine( OSR) on the EEG changes and its power spectrums of cerebral frontal cortex in anaesthetized rats. Methods With the equipment of brain stereotactic apparatus,electrode was implanted into frontal lobe of cerebral cortex in rats. Unipolar lead and computerized FFT technique were employed to record the index of EEG,power spectrum and frequency distributions to analyze the effect of OSR on the bioelectricity altera-tions of frontal lobe in cerebral cortexi in rats. Results Administrated( icv) with OSR at the dose of 2. 5,5, 10 mg/rat in rats,the EEG of frontal lobe of cerebral cortex was mainly featured by low amplitude and slow waves accompanied by spindle-formed sleeping waves with a significant decrease of total power of EEG( P
