Study on correlation of genetic polymorphism of PRKAA2 with metformin response
- VernacularTitle:PRKAA2基因多态性与二甲双胍疗效的相关性研究
- Author:
Jiane LI
;
Yi LAN
;
Linlin LI
;
Xudong BAI
;
Xinmin MAO
- Publication Type:Journal Article
- Keywords:
polymorphism;
single nucleotide;
PR- KAA2;
metformin;
type 2 diabetes mellitus;
DGGE
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the single nucleotide poly-morphism ( SNPs ) of AMP-activated protein kinase ( AMPK) ?2 subunit gene PRKAA2 ( rs2051040 and rs17848595) and its relationship with metformin response. Methods A total of 32 patients with type 2 diabetes( T2DM) were enrolled. All patients were required to take metformin for 1 week. The serum levels of FPG,TG,TC,LDL-C,HDL-C were assayed before and after therapy. The gene polymorphism of PRKAA2 was analyzed by PCR-DGGE,the effects of metformin were compared between patients with different phenotypes. Results FPG,TG,TC,LDL-C were significantly improved after therapy in wild genotype carriers( P 0. 05) . Conclusion The results of this study suggest that PRKAA2 polymorphism may be associated with metformin treatment effects in T2DM patients.
