JNK signal transduction pathway participated A?-induced neuronal injury in rat hippocampus
- VernacularTitle:JNK信号通路参与A?毒性对大鼠海马神经元的损伤
- Author:
Weihong CONG
;
Jianxun LIU
;
Bin YANG
;
Xiaoxia DONG
- Publication Type:Journal Article
- Keywords:
JNK signal transduction pathway;
?-amyloid peptide;
hippocampus;
neuron;
apoptosis;
rat
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the hippocampal neuronal injury induced by ?-amyloid peptide ( A?) in rats and the candidate contribution of JNK signal transduction pathway to A? toxicity. Methods Rats were bilaterally injected with A?1 -40 into hippocampi CA1 area. The pathological changes,survival and apoptosis,and ultrastructure of hippocampal neurons,as well as p-JNK positive cells were observed by HE staining,Nissl staining,TUNEL staining,immunohistochemistry and transmission electron microscopy,respectively. Results Thepyramidal cells in hippocampus arranged loosely with decreased cell number. The gliacytes significantly proliferated. Significant apoptotic features were observed in CA1 ultrastructure. TUNEL-positive cells and p-JNK-positive cells significantly increased ( P
