Advanc in research of the effects of Drebrin on synaptic plasticity and related cognitive dysfunction
- VernacularTitle:Drebrin对突触可塑性的影响以及相关认知功能障碍的研究进展
- Author:
Lijie JIA
;
Yan LUO
;
Fujun ZHANG
;
Buwei YU
- Publication Type:Journal Article
- Keywords:
Drebrin;
spiny plasticity;
synaptic plasticity;
mechanism;
regulate;
cognitive dysfunction
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
As the neuron-specific actin binding protein,Drebrin ( developmentally regulated brain protein) can affect spiny and synaptic morphology and function by changing the property of cytoskeleton,and modulate synaptic plasticity. Neural excitability regulates expression and activitiy of Drebrin through a variety of signaling molecules,making Drebrin' s function correlated with that of neurons. Under pathological conditions,the abnormal Drebrin affects synaptic plasticity,which leads to different degrees of cognitive dysfunction,and it is closely relates to the progress of cognitive dysfunction. Extensive studies of physiological and pathological functions of Drebrin in overall and molecular ways will not only contribute to a thorough understanding of cognitive dysfunction,but also develop the new target of therapeutics for cognitive dysfunction.
