Effects of different ways of administration on the P2X_1 purinoceptor-mediated vasoconstriction in the rat mesenteric artery
- VernacularTitle:不同给药方式对P2X_1受体介导大鼠肠系膜动脉收缩反应的影响
- Author:
Lu LI
;
Leiming REN
- Publication Type:Journal Article
- Keywords:
?,?-methylene ATP;
administration regimes;
P2X1 purinoceptor;
vasoconstriction;
mesenteric artery;
rat
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of ?,?-methylene ATP ( ?,?-MeATP) on the P2X1 purino-ceptor-mediated vasoconstriction by different administration ways in the rat mesenteric artery. Methods Isometric vasoconstrictive responses to ?,?-MeATP,administered in non-accumulative manner or single concentration manner,were recorded in the rat isolated mesenteric arterial rings. Results ?,?-MeATP ( 10 -7 ～ 10 -4 mol ? L -1 ) administered in both of the two manners produced concentration-dependent vasocon-strictive responses in the rat isolated mesenteric artery. The vasoconstrictive responses to ?,?-MeATP in single-concentration administration group were greater than those in non-accumulative administration group when the vasoconstriction was standardized either by tissue wet weight or by maximal response to 120 mmol ?L-1 KCl ( P
