Experimental study of effect of Xiaoliu Granule on hysteromyoma rat
- VernacularTitle:消瘤颗粒对子宫肌瘤模型大鼠影响的实验研究
- Author:
Hui MO
;
Li XU
;
Qianwen LIN
;
Jie SUN
;
Qichang ZHENG
- Publication Type:Journal Article
- Keywords:
Xiaoliu Granule;
Hysteromyoma;
ER;
PR;
Apoptosis;
Experimental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Xiaoliu Granule (XLG) is based on the principle of Yiqi Huayu Decoction, this experiment was to study the treating point of XLG on the hysteromyoma rats. Methods: The hysteromyoma rats models was established in rats by loading estrogen and progesterone, to observe the effect of XLG on pathological condition of uterus, and the content of PR , ER, Bcl-2/Bax. Results: The experiments proved that XLG was effective in reducing the proliferation, reversing the proliferative abnormalities of uterus smooth muscle. The XLG also can significantly reduce the content of PR, ER and Bcl-2/Bax. Conclusion: Therefore, XLG was a good approach in treating hysteromyoma. The mechanism of XLG in treating hystermyoma was probably by reducing ER, PR, lowering the E, P sensitivity; reducing expression of Bcl-2, increasing the expression of Bax, and promoting cell apoptosis, etc.
