Distribution of basic fibroblast growth factor and its receptor in minipig heart after myocardial infarction
- VernacularTitle:碱性成纤维细胞生长因子及其受体在心肌梗死心脏组织中的分布
- Author:
Yunyun XU
;
Jianming XIAO
;
Ruiyun ZHANG
;
Min ZHANG
;
Baihui YANG
- Publication Type:Journal Article
- Keywords:
fibroblast growth factor 2;
receptor,fibroblast growth factor,type 1;
myocardial infarction;
swine;
immunohistochemistry
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution and changes of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in normal heart or heart after myocardial infarction (MI),and to explore beneficial effects of bFGF on heart after MI. Methods Eleven adult minipigs were randomly divided into 2 groups,control (n=5) and MI group (n=6). MI was induced by ligating the left anterior descending coronary artery. Sham-operation was carried out on the animals of control. bFGF-like-immunoreactivity (bFGF-ir) and FGFR-1-like-immunoreactivity (FGFR-1-ir) in heart tissues were detected by immuno-histochemistry and image analysts in 4 weeks after surgery. Results In controls,bFGF-ir and FGFR-1-ir in the atrium showed a considerable high level compared with 2 ventricles (P
