Relaxant effects of total flavonoids of buckwheat flowers and leaves on rat thoracic aorta and underlying mechanisms
- VernacularTitle:荞麦花叶总黄酮的舒张血管作用及其机制
- Author:
Bonan ZHANG
;
Jinxiu CHU
;
Shuying HAN
- Publication Type:Journal Article
- Keywords:
total flavonoids of Buckwheat flowers and leaves;
vasorelaxation;
nitric oxide;
Ca~2+ channel;
thoracic aorta ring;
laser scanning confocal microscope
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the vasodilative effect on rat thoracic aortic ring of total flavonoids of Buckwheat flowers and leaves(TFBFL) and the underlying mechanisms.Methods Isometric tension measurements were used to study the effect of TFBFL on isolated rat thoracic aorta rings.Laser scanning confocal microscope was employed to measure the concentration of intracellular free calciums.Results In aorta rings precontracted with phenylephrine or potassium chloride,TFBFL caused a dose-dependent relaxation in both endothelium-intact and denuded rings and the relaxant effect of TFBFL was more potent on endothelium-intact aorta rings than that on endotheliumdenuded aorta rings(P
