Development and application of models for screening torsade de pointes induced by drugs
- VernacularTitle:药物诱发尖端扭转性室性心动过速筛选模型的发展与应用
- Author:
Qiangni LIU
;
Fandian ZENG
- Publication Type:Journal Article
- Keywords:
drug-induced arrhythmia;
torsade de pointes;
in vivo models;
in vitro models;
hERG;
Ca~2+i
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,a large number of drugs have been withdrawn from the market because of torsade de pointes(TdP) and sudden cardiac death,which pose great risks in drug application.Therefore,the different models have been developed to detect TdP liability during the early stage of drug development.In this paper,the principles and characteristics of these screening models are reviewed to give props for preclinical safety assessment.
