Nucleotide signals in the central nervous system and microglial movements
- VernacularTitle:中枢神经系统核苷酸信号与小胶质细胞活动
- Author:
Qin LI
;
Juntian ZHANG
;
Minke TANG
- Publication Type:Journal Article
- Keywords:
microglial movements;
nucleotide;
purinergic receptors;
chemotaxis;
phagocytosis;
process retraction
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Microglia cells are immune cells in the central nervous system.When the microenvironment of brain has changed,microglia will respond rapidly.ATP,UTP,or other nucleotide signals released by neurons from damaged site and their metabolites such as ADP,adenosine,UDP and so on will bind with the purinergic receptors on microglia to regulate the morphology and function of microglia,then the microglial cells activated by nucleotide signals are to regulate neural cells by phagocytosis or releasing cytokines.In this article,the function and corresponding mechanisms of nucleotide signals on chemotaxis,phagocytosis,and process retraction are reviewed.
