Effect of electroacupuncture on cell proliferation and differentiation in dentate gyrus of aged rats with focal cerebral ischemia reperfusion injury
- VernacularTitle:电针干预对老龄大鼠脑缺血再灌注海马内源性神经干细胞增殖分化的影响
- Author:
Jianfeng GAO
;
Fenghua LV
;
Changlian ZHU
- Publication Type:Journal Article
- Keywords:
Electroacupuncture;
Aged;
Cerebral ischemia reperfusion;
Neural stem cell;
Proliferation;
Differentiation;
Rat
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the protective effect of electroacupuncture on stem cell proliferation and differentiation in dentate gyrus (DG) in aged rats with focal cerebral ischemia reperfusion injury. Methods:We duplicated focal cerebral ischemia model with MCAO,with ischemia 3h,I/R1,3,7,14,21d points. The effect of electroacupuncture on the nervous dysfunction score,the water content of cerebral constitution and the stem cell proliferation and differentiation in dentate gyrus were observed,and the non-acupoint group was as control. Results:The nervous dysfunction score (all the time points),the water content of cerebral tissue (I/R1,3,7d),BrdU positive cells (all the time points),BrdU/NeuN positive cells (all the time points),BrdU/GFAP positive cells (I/R7,14,21d),in model group were higher than those of the sham-operated group (P
