Effect of Shenfu Injection on expression of HO-1 and iNOS in renal failure rats induced by intestinal ischemia-reperfusion
- VernacularTitle:参附注射液对肠缺血再灌注大鼠肾组织HO-1与iNOS表达的影响
- Author:
Yang WU
;
Zhongyuan XIA
- Publication Type:Journal Article
- Keywords:
Kidney injury;
Intestinal ischemia-reperfusion;
HO-1;
iNOS;
Shenfu Injection
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of Shenfu Injection (SFI) on expression of Heme oxygenase-1 (HO-1) and iNOS (inducible nitric oxide synthase) in renal failure rats induced by intestinal ischemia-reperfusion (IR) and its possible mechanism. Methods:The model of intestinal ischemia-reperfusion was induced by clamping superior mesenteric artery for one hour and then releasing the arterial clamp for six hours. Wistar rats were randomized into three groups:IR+normal saline group,IR+SFI group and control group (C group). The serum creatinine and blood urea nitrogen were observed respectively. Expression of HO-1 and iNOS in rat kidney tissue was detected by immunohistochemitry and morphometry computer image analysis. The histological change of kidney was observed under light microscope. Results:①Compared with C group,expression of HO-1 and iNOS increased markedly in IR+ normal saline group (P
