Effects of Zhitaiqing Granule on aortic endothelial cellsIn rabbit with experimental atherosclerosis
- VernacularTitle:脂汰清颗粒对实验性动脉粥样硬化兔主动脉内皮细胞的影响
- Author:
Shilong YE
;
Aiqin LIU
;
Ning SU
;
Yongbin ZHANG
- Publication Type:Journal Article
- Keywords:
Zhitaiqing Granule;
Hyperlipidemia;
Atherosclerosis;
Pathology
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of Zhitaiqing Granule on aortic endothelial cells in rabbit with experimental atherosclerosis. Methods:10 New Zealand rabbits were selected as blank control randomly and fed with normal forage,while the rest rabbits were fed with high-fat forage in formula A. After six weeks,hyperlipidemia models were formed and they were randomly divided into model group,Zhitaiqing treatment group,simvastatin control group and hawthorn tablet control group. From the 7th week,rabbits in treatment and control groups were fed with corresponding drugs while the blank and model groups with the same quantity of normal saline by lavage. After 11 weeks lavage,total cholesterol (CHO),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),apolipoprotein AI (apo AI),apolipoprotein B (apo B).were detected. With the help of optical microscope,the pathological changes of the aortic arch,thoracic aorta and abdominal aortic intima were observed. Results:In Zhitaiqing group,CHO,LDL-C,and ApoB reduced dramatically (P
