Effect of telmisartan on oxidative stress in type 1 diabetic rats
- VernacularTitle:替米沙坦对1型糖尿病大鼠氧化应激的影响
- Author:
Xiang TANG
;
Xunmin CHEN
;
Shisen JIANG
;
Dan SONG
- Publication Type:Journal Article
- Keywords:
diabetes mellitus,type 1;
telmisartan;
oxidative stress
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of telmisartan on oxidative stress in type 1 diabetic rats.Methods Type 1 diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ) in adult male Wistar rats.Sixteen diabetic rats were randomly divided into two groups (8 each):diabetic mellitus group (DM) and telmisartan group (T).Eight normal rats were employed as the control group (Con group).After 12 weeks,body weight (BW) and heart weight (HW) were measured to calculate HW/BW.Glutathione (GSH),malondialdehyde (MDA),the activity of superoxide dismutase (SOD) were evaluated by spectrophotometer.Ultrastructure of myocardial cells was observed by transmission electron microscope.Results There was no significant difference in blood glucose levels between DM group and T group at the 7th day and 12th week after STZ injection,but the blood glucose levels in the both groups were significantly higher than that in Con group (P0.05).The MDA level was higher (P
