Effects of telmisartan on mitochondrial membrane potential and cardiomyocyte apoptosis in type 1 diabetic rats
- VernacularTitle:替米沙坦对糖尿病大鼠心肌线粒体膜电位及心肌细胞凋亡的作用
- Author:
Xiang TANG
;
Xunmin CHENG
;
Shisen JIANG
;
Dan SONG
- Publication Type:Journal Article
- Keywords:
diabetes mellitus,type 1;
membrane potential,mitochondrial;
myocardium;
apoptosis;
telmisartan
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of telmisartan on mitochondrial membrane potential and cardiomyocyte apoptosis of rats with type 1 diabetes.Methods Type 1 diabetic rat model was reproduced by intraperitoneal injection of streptozotocin to adult male Wistar rats.Sixteen diabetic rats were randomly divided into two groups (8 each):DM group and T group (rats were treated with telmisartan).Another 8 normal rats served as control (Con group).After 12 weeks,the levels of reactive oxygen species (ROS) were detected by fluorescent probe DCFH-DA,and the changes in mitochondrial membrane potential (?m) was detected by fluorescent probe JC-1.Cardiomyocyte apoptosis was evaluated by TUNEL.Results The levels of blood glucose were higher and body weight was lower in both DM and T group than in Con group at 7th day and 12th week after streptozotocin injection (P
