Expressions and significances of EMMPRIN,MMP-2,MMP-9 and VEGF in endometriosis
- VernacularTitle:细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶与血管内皮生长因子在子宫内膜异位症中的表达及意义
- Author:
Jing ZHANG
;
Liangdan TANG
;
Min ZHOU
;
Xingtao LONG
- Publication Type:Journal Article
- Keywords:
endometriosis;
antigens,CD147;
matrix metalloproteinases;
vascular endothelial growth factors
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and significances of extracellular matrix metalloproteinase inducer (EMMPRIN),the matrix metalloproteinases-2,-9 (MMP-2,-9),and the vascular endothelial growth factor (VEGF) in endometriosis (EM). Methods The expressions of the EMMPRIN,MMP-2,MMP-9 and VEGF were detected by SABC immunohistochemistry in 57 tissue samples of ectopic endometrium and 51 samples of eutopic endometrium obtained from 57 EM patients,and in 48 normal endometrium from patients with non-endometriosis. Correlation analysis was carried out on the expressions of these proteins and pathologic staging. Results The EMMPRIN,MMP-2,MMP-9 and VEGF in ectopic endometrium were expressed at significantly higher levels (0.723?0.114,0.729?0.109,0.692?0.089,0.704?0.103,respectively) than those in eutopic endometrium group (0.396?0.097,0.365?0.023,0.349?0.030,0.370?0.129,respectively,P
