EFFCT OF AJOENE ON THROMBOSIS AND ITS POSSIBLE MECHANISM
- VernacularTitle:阿藿烯对血栓形成的影响及其机制
- Author:
Xiaolin ZHANG
;
Xiangnian ZHANG
;
Anping YANG
;
Aiping LIU
;
Shujin ZHAO
- Publication Type:Journal Article
- Keywords:
ajoene;
thrombosis;
platelet aggregation;
P-selectin;
vascular cell adhesion molecule-1
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ajoene on thrombosis and explore the possible mechanism.Method SD rats were randomly divided into five different groups and administered ajoene in 7d.The effect of ajoene on thrombosis in rats was observed with the thrombogenesis model of artery-vein bypass.The serum level of vascular cell adhesion molecule-1(VCAM-1) and P-selectin(Ps)were measured.To observe the effect of ajoene on platelet aggregation,arachidonic acid was used to induce platelet aggregation and platelet function was evaluated by turbidimetry in rabbit.Results Ajoene significantly inhibited the the thrombosis of artery-vein bypass in rats and reduced rate of platelet maximal aggregation and decreased the P-selectin concentration in serum at 25,50,75mg/kg (P
