RELATIONSHIP BETWEEN SERUM CALCIOTROPIC HORMONE LEVELS AND COL1A2 GENE,OC GENE POLYMORPHISMS IN CHILDREN
- VernacularTitle:儿童钙代谢相关激素与Ⅰ型胶原及骨钙素基因多态性关系的分析
- Author:
Yue BA
;
Yuejin YANG
;
Zhenxin GENG
;
Xuemin CHENG
;
Jie LIU
;
Liuxin CUI
- Publication Type:Journal Article
- Keywords:
COL1A2 gene polymorphism;
OC gene polymorphism;
osteocalcin;
calcitonin;
calcium
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the relationship between polymorphisms in the collagen type I alpha 2 (COL1A2),osteocalcin (OC) gene and serum calciotropic hormone levels.Method One hundred twenty-two healthy children aged 8-12 years old were recruited.The Pvu Ⅱ and Rsa Ⅰ polymorphisms in the COL1A2 gene and Hind Ⅲ polymorphism in the OC gene were determined using the PCR-RFLP procedure.Calcitonin(CT) and OC levels in the serum were measured using radioimmunassays.Results The calcium and CT in serum of children carrying the homozygous genotype RR were found to be significantly higher compared to children carrying the homozygous genotype rr (P
