Experimental study on Baicalein inhibiting the invasion and migration of human breast cancer cells
- VernacularTitle:黄芩素抑制人乳腺癌细胞侵袭和迁移的实验研究
- Author:
Xiufeng WANG
;
Qianmei ZHOU
;
Shibing SU
- Publication Type:Journal Article
- Keywords:
baicalein;
breast cancer;
invasion;
migration;
metastasis;
MDA-MB-231
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effect of Baicalein and its mechanism on the invasion and migration of human breast cancer MDA-MB-231 cells.Methods The effect of Baicalein on cell viability was tested by MTT.The cell invasion and migration were determined by transwell chamber model.The cell movement capability was determined by cell scratch assay.The expressions of matrix metalloproteinase(MMP)2 and 9,urokinase-type plasminogen activator(uPA)were detected by Western blot.Results 50,100 ?mol?L-1 of Baicalein inhibited significantly cell invasion(P
