Effects of Clausenamide on hippocampus COX-2 mRNA and protein expressions in diabetic rats
- VernacularTitle:黄皮酰胺对糖尿病大鼠海马COX-2 mRNA和蛋白质表达的影响
- Author:
Ruanling HOU
;
Xianhong DONG
;
Nana LI
;
Lin LIU
;
Jun LIN
;
Dongliang LI
- Publication Type:Journal Article
- Keywords:
Clausenamide;
diabetes mellitus;
rat;
streptozotocin;
hippocampus;
cyclooxygenase-2
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effects of Clausena-mide(Clau) on hippocampus cyclooxygenase-2 (COX-2) mRNA and protein expressions in diabetic rats. Methods The diabetic rat model was produced by injecting streptozotocin (STZ,48 mg?kg-1). After 3 months,the COX-2 gene and protein expressions in hippocampus of diabetic rats were detected by RT-PCR and immunohistochemistry respectively. Results ① The results of RT-PCR showed that the expression of COX-2 mRNA in hippocampus of diabetic group rats increased significantly (P
