High brain iron in etiology of Alzheimer's disease and therapeutic approaches
- VernacularTitle:铁超载促进阿尔采末病的发展及其相关治疗
- Author:
Yimin SUN
;
Weina KONG
;
Guangzhi LI
;
Xiqing CHAI
- Publication Type:Journal Article
- Keywords:
Alzheimer' s disease;
iron;
reactive oxygen species;
?-amyloid protein;
cell cycle;
iron-chelating drugs
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Excessive iron accumulation in the brain occurs in Alzheimer' s disease (AD) with oxidative stress,amyloid deposition,tau phosphorylation,and neuronal cell cycle regulatory failure,leading to apoptosis.Therefore,there is a direct link between iron metabolism and AD pathogenesis. The present review elaborates on high brain iron in etiology of AD and the development of iron-chelating therapy for AD,aiming at preventing or slowing down disease evolution.
