The brain pharmacokinetical study of different diameters neurotoxin-Ⅰ nanoparticles after intranasal administration in rats
- VernacularTitle:不同粒径神经毒素-Ⅰ纳米粒大鼠鼻腔给药脑药动学研究
- Author:
Qiang BAO
;
Xinjun CAI
;
Fanzhu LI
- Publication Type:Journal Article
- Keywords:
neurotoxin-Ⅰ;
Methylated-polyethyleneglycol;
particle diameter;
nanoparticle;
rats;
intranasal administration;
microdialysis;
brain pharmacokinetics
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To prepare NT-Ⅰ loaded nanoparticles with different diameters modified by Methylated-polyethyleneglycol (Me-PEG) and evaluate their brain pharmacokinetics after administered nasally in rats. Methods NT-Ⅰ-NP was prepared by emulsion/solvent evaporation method and MePEG-PLA was used as the carrier material. Microdialysis technique and fluorospectrophotometry were used to determine NT-Ⅰ concentration after nasal administration in the brain of rats. Results The appearance of all NT-Ⅰ-NP groups was round or similar. The AUC(0-t) of below 100 nm NT-Ⅰ-NP was 1.22 fold as that of 100~200 nm NT-Ⅰ-NP,1.34 fold as that of 200~300 nm and 1.60 fold as that of exceed 300 nm NT-Ⅰ-NP(P
