Applicable traditional dose of CRRT for critically ill patients with AKI
- VernacularTitle:传统持续性肾脏替代治疗危重病合并急性肾损伤合适剂量探讨
- Author:
Li WANG
- Publication Type:Journal Article
- Keywords:
acute kidney injury;
critical illness;
continuous renal replacement therapy;
renal replacement therapy
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AKI is one of the frequent complications of critically ill patients,which is associated with high mortality.RRT is the main treatment,especially CRRT nowadays.But the optimal dosage of CRRT is unclear.In this article,we will review the evidence of CRRT in critically ill patients with AKI.Compared with traditional dosage of CRRT,high dose CRRT did not improve the clinical outcome.There was no difference in mortality rate,time for renal recovery,ICU hospitalization time,or organ failure in both groups,while there were more complications including hypokalemia and hypophosphatemia in the high dose CRRT group.Treatment with high dose CRRT could alter drug metabolism,cause malnutrition,unbalance the electrolyzes and cause hypothermia.So we conclude that traditional dosage of CRRT[20～35 mL/(kg?h)]is applicable for critically ill patients with AKI,but the determination of optimal dose depends on many clinical situations other than clearance of small solutes.
