Study of the effect of iron overload on the bone marrow hematopoietic function in immuo-related pancytopenia patients
- VernacularTitle:高铁负荷对免疫相关性全血细胞减少症骨髓造血功能影响的研究
- Author:
Yili GU
;
Zonghong SHAO
;
Rong FU
;
Yong LIANG
;
Wen QU
;
Huaquan WANG
;
Guojin WANG
;
Jia SONG
;
Hong LIU
;
Yuhong WU
;
Limin XING
;
Jing GUAN
;
Jun WANG
;
Lijuan LI
;
Xiaoming WANG
;
Erbao RUAN
- Publication Type:Journal Article
- Keywords:
immno-related pancytopenia;
serum ferritin;
hematopoietic progenitor cells
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of iron overload on the bone marrow hematopoietic function on immuo-related pancytopenia(IRP)patients by hematopoietic progenitor cell(HPC)culture of bone marrow(BM).Methods BM liquid 4～5 mL was taken from 46 IRP patients of General Hospital Tianjin Medical University from July 2009 to February 2010 to detect colony-forming-unit of erythrocyte,blast-forming-unit of erythrocyte and colony-forming-unit of granulocyte-monocyteby HPC culture of BM.And according to the serum ferritin(SF)level,these patients were classified into 2 groups to compare HPC proliferation,blood cell counts,BM proliferation,blood transfusion and treatment effects.Results The mean values of 3 different colonies of IRP patients with high SF level [(43.33?17.74),(1.50?2.2),(11.06?5.83)/105BMMNC] were significantly lower than those of the patients with normal SF level [(77.43?40.64),(9.57?7.99),(21.25?11.41)/105BMMNC](P
