New opinion of chronic renal disease:the effects of ADMA on the progress of the disease
- VernacularTitle:非对称二甲基精氨酸与慢性肾脏病心血管并发症关系研究进展
- Author:
Wei ZHANG
;
Weijie YUAN
- Publication Type:Journal Article
- Keywords:
ADMA;
DDAH;
CKD
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Asymmetric dimethylarginine(ADMA)is a natural L-arginine analogue that reduces the bioavailability of nitric oxide in plasma and various types of tissues,acting as an endogenous NO synthase inhibitor in vivo.ADMA is considered a common pathway mediating the adverse vascular effects of traditional and nontraditional risk factors.These preclinical findings are thought to be of major importance as ADMA predicts cardiovascular events and mortality in patients with chronic kidney disease(CKD).Also,ADMA uniformly predicts the progression of moderate and severe CKD.The present study summarizes the latest developments in this field.
