Synthesis of 6?-butylaminocholestan-3?,5?-diol,an analogue of anti-tumoral dendrogenin
- VernacularTitle:树化胺基甾醇类似物6?-丁胺基胆甾-3?,5?-二醇的合成
- Author:
Bo FANG
;
Linghui TAO
;
Xiangdong ZHOU
;
Chenghe ZHOU
- Publication Type:Journal Article
- Keywords:
cholesterol;
dendrogenins;
imidation-reduction of one-pot two steps;
antitumor
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize 6?-butylaminocholestan-3?,5?-diol,a new analogue of anti-tumoral dendrogenin with a new method.Methods 6?-butylaminocholestan-3?,5?-diol was synthesized in 5 steps using cholesterol as the starting material,3?,5?-dihydroxyl-cholestan-6-one as the key intermediate and imidation-reduction of one-pot 2 steps as the key steps.Results The target compound was synthesized in a total yield of 62% and its structure were consistent with MS (476),HRMS (476.446 5),[?]25D(-57.0?),IR (3387),1HNMR [2.67～2.61 (1H,m,6?-H)],13CNMR spectrum and elemental analyses.Conclusion Our synthetic route to 6?-butylaminocholestan-3?,5?-diol is characterized by easily available and cheap starting material,high total yield and easy industrialization.
