Ischemic preconditioning improves myocardial insulin resistance after calcium overload in rat cardiac myocytes
- VernacularTitle:缺血预处理改善心肌钙超载后胰岛素抵抗
- Author:
Huanwen CHEN
;
Ming DU
;
Yonggang LI
- Publication Type:Journal Article
- Keywords:
cardiomyocyte;
insulin resistance;
ischemic preconditioning
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).Resting [Ca2+]i in normal cardiac muscle cells was (117?22.41) nmol/L,while for the cells of experimental groups 1 and 2,it was significantly higher than normal cells,but there was no significant difference between them after 1 hour’s treatment of 0.5 ?mol/L ionomycin [(260.00?33.06) and (278?23.46) nmol/L respectively].The [Ca2+]i in experimental groups 3 and 4 was (391.00?20.01),and (379.00?23.92) nmol/L respectively,which were significantly higher than those of experimental groups 1 and 2,and control group (P
