Effects of rosiglitazone on serum inflammatory mediators and early skin changes in diabetic rats
- VernacularTitle:罗格列酮对糖尿病大鼠血清炎性介质和早期皮肤改变的影响
- Author:
Xiaofei ZHANG
;
Fei HAO
;
Jing YANG
- Publication Type:Journal Article
- Keywords:
diabetes mellitus;
rosiglitazone;
inflammatory factor;
superoxide dismutase;
pathology;
skin thickness
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of rosiglitazone on serum levels of tumor necrosis factor-? (TNF-?),interleukin-6 (IL-6),C-reactive protein (C-RP) and superoxide dismutase (SOD),and early skin changes in the diabetic rats.Methods The rats were divided into normal control group (C group,n=13),diabetic control group (DC group,n=13),diabetes and insulin treatment group (DI group,n=13),diabetes and rosiglitazone treatment group (DR group,n=13).The diabetic rat models were established with high-fat diet for 2 weeks followed by intraperitoneal injection of 35 mg/kg streptozotocin injection,the rats were idenfied as diabetic when their fasting blood glucose (FBG) over 7.0 mmol/L.The living rats were given corresponding treatment,subcutaneous injection of 1 to 2 U/d insulin,intragastric injection of 5 mg/(kg?d) rosiglitazone,or sterile water.Heart blood samples of rats from each group were collected to measure TNF-?,IL-6,C-RP and SOD levels in the 16th weekend.Also the skin was taken for pathological observation and full-thickness as well as dermal thickness measurements.Results The serum levels of IL-6,TNF-? and C-RP in diabetic group were significantly higher than those in normal group (P
