Protective effects and the mechanisms of DEAAA on focal cerebral ischemia in rats
- VernacularTitle:(E)-3-(4-(2-(二甲氨基)乙氧基)-3-甲氧苯基)丙烯酸对大鼠局灶性脑缺血的保护作用及机制
- Author:
Rui JI
;
Li CHEN
;
Yulin WU
- Publication Type:Journal Article
- Keywords:
Ozagrel;
Focal cerebral ischemia;
Protective effects;
Anoxia
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the protective effects of (E)-3-(4-(2-(dimethylamino) ethoxyl)-3-anisyl) acrylic acid(DEAAA) on focal cerebral ischemia of rats. METHODS:Middle cerebral artery occlusion(MCAO) model was used to evaluate the drug's effects. With Ozagrel as a positive control drug,after cerebral ischemia,the effect of different doses of DEAAA on the neurological behaviors,the cerebral water volumes,the cerebral infarction areas,the cerebral biochemistry and the pathologic change of brains were evaluated. RESULTS:DEAAA (30,18 mg/kg) decreased the cerebral water volumes and the cerebral infarction areas(P
