Haloperidol induced long QT interval and effects on L-type calcium channel mRNA expression of New Zealand rabbit
- VernacularTitle:氟哌啶醇致新西兰兔QT间期延长及其对L型钙通道mRNA表达水平的影响
- Author:
Abdurahman ADIL
;
Dong YAN
;
Zhou ZOU
;
Keram PARHAT
- Publication Type:Journal Article
- Keywords:
haloperidol;
New Zealand rabbit;
arrhythmia;
QT interval;
RT-PCR;
mRNA
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the influence of haloperidol on QT interval and effects on L-type calcium channel mRNA expression.Methods By surface ECG technique and RT-PCR technique observe the influence of Various doses haloperidol to New Zealand rabbits ECG.And L-type calcium channel mRNA.Results Haloperidol elongated the QT interval.Haloperidol influence QT interval mainly happened after from 0 minutes to 120 minutes.360 minutes later,QT interval turned to normal standard.RT-PCR result display haloperidol obviously increase L-type calcium channel mRNA expression.Conclusion Haloperidol can prolong the QT interval.and it's mechanism concerned with increase L-type calcium channel mRNA expression.So,it can increase the risk of ventricular arrhythmias occur.
