The relationship between TGF-?_1-mediated Smads and ERK in the progression of pulmonary fibrosis
- VernacularTitle:TGF-?_1介导的Smads与ERK通路在肺纤维化中的作用及相互关系
- Author:
Yaru YANG
;
Yan HUANG
;
Jun LI
- Publication Type:Journal Article
- Keywords:
transforming growth factor-?1;
Smads;
ERK;
pulmonary fibrosis;
pulmonary fibrosis;
signalling pathway
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Mitogen activated protein kinase(MAPK)is one of the four biggest signal transduction systems which contain four subtribes named p38,ERK5/BMK1,ERK and JNK/SAPK respectively.Previous studies have shown that MAPK pathway is involved in growth,cell differentiation,perishing,the synchronization of cell function and so on.ERK/MAPK,one of the members of MAPK family,and Sma-and MAD-related(Smad)play important roles in the proliferation of fibroblast,modulating inflammation mediator production as well as transferring factors activity in the process of pulmonary fibrosis(PF).This review focuses on relationship between Smads and ERK in the pathogenesis and progression of PF.
