Effect of Cortex Phellodendron on Nephritic Rats' Tumor Necrosis Factor Alpha and Cyclooxygenase 2
- VernacularTitle:黄柏对尿酸性肾病大鼠肾组织肿瘤坏死因子?及环氧化酶-2表达的影响
- Author:
Jiacai HU
- Publication Type:Journal Article
- Keywords:
Cortex phellodendron;
uric acid nephropathy;
tumor necrosis factor alpha;
cyclooxygenase-2
- From:
Journal of Zhejiang Chinese Medical University
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To observe the effect and mechanism of cortex phellodendron on uric acid nephropathy.[Methods]32 male SD rats were divided into four groups including control group,model group,cortex phellodendron treated group and allopurinol treated group.Uric acidnephropathy model rats were established by using yeast and adenine,then treated with Sodium Chloride,cortex phellodendron or allopurinol respectively for 30 days.Blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA)in blood were examined,and the expressions of tumor necrosis factor alpha(TNF-?)and cyclooxygenase 2(COX-2)in renal tissue were detected by immunohistochemistry technique.[Results]Compared with model group,the levels of BUN,Cr,UA in blood and the expression of COX-2 and TNF-? in renal tissue in cortex phellodendron treated group decreased significantly.[Conclusion]Cortex phellodendron has a beneficial effect on uric acid nephropathy in rats.It could decrease the expression of TNF-? and COX-2 in renal tissue of uric acid nephropathy rats so as to alleviate the damage of kidney and protect renal function.
