Suppression Effect of Di-n-butyl Phthalate in vitro on Superoxide Dismutase of Various Organs of Mice
- VernacularTitle:邻苯二甲酸二丁酯对大鼠不同器官细胞SOD抑制作用的研究
- Author:
Meng WANG
;
Fengyun CAI
;
Xu YANG
- Publication Type:Journal Article
- Keywords:
Di-n-butyl phthalate (DBP);
Oxidative damage;
SOD
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The present study was conducted to study the oxidation damage effects of DBP on organs of mice and the molecular mechanisms of the effects. Methods The cells of the organs (liver,kidney,testis,lung) were exposed to different concentration of DBP (0?mol/L,5?mol/L,20?mol/L,80?mol/L) for one hour in vitro,and then the superoxide dismutase (SOD) activities of those cells of different organs were measured. Results With statistical significance,the SOD activities in liver,kidney,testis,lung cells were increased gradually with the increase of DBP concentrations. Conclusion The results suggested that DBP could induce the oxidative damage in liver,lung,kidney and testis cells of mice.
